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KMID : 0895820070170040001
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Journal of Oriental Rehabilitation Medicine
2007 Volume.17 No. 4 p.1 ~ p.21
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Effects of Yukmijiwhang-tang(Liuweidihuang-tang) with Puerariae Radix on Ovariectomized Osteoporotic Rats
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Han Myung-Kum
Kwon Young-Dal
Song Yung-Sun
Lee Chong-Woo
Won Jae-Kyun
Kwon Young-Mi
Kim Cheol-Han
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Abstract
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Objectives :This study was performed to investigate the effects of Yukmijiwhang-tang (Liuweidihuang-tang) with Puerariae raidx(YMG) on the ovariectomized rat model of postmenopausal osteoporosis.
Methods :We used 9 week aged Sprague-Dawley rat and divided into four group, sham operation group(Control, C), ovariectomized group(Negative Control, N.C), administrated YMG 1,250 mg/kg/day after ovariectomy group(T1), administrated YMG 2,500 mg/kg/day after ovariectomy group(T2). Then we observed changes in the body weight, body fat, serum metabolic products, bone density and so on.
Results :1. Body weight in negative control group showed significant increase in comparison with control group, but that in T1 and T2 group showed decrease in comparison with negative control group. 2. In the autopsy, negative control group showed uterus atrophy in comparison with control group. While T1 and T2 group showed decrease in uterus atrophy in comparison with negative control group. 3. In the total cholesterol, negative control group showed a significant increase in comparison with control group. While T1 and T2 group showed a significant decrease in comparison with negative control group. 4. In the body fat, negative control group showed a tendency to increase in comparison with control group. While T1 and T2 group showed a tendency to decrease in comparison with negative control group. 5. In bone density, normal control group showed a tendency to decrease bone density in comparison with control group. While T1 and T2 group showed a tendency to increase bone density in comparison with negative control group.
Conclusion :YMG has shown to be capable of preventing and curing osteoporosis induced by ovariectomy osteoporosis rats.
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KEYWORD
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Osteoporosis, Yukmijiwhang-tang(Liuweidihuang-tang), Puerariae radix, Ovariectomy
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